In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria | Zendy

Hannah M. Wexler | Zendy; B Harris | Zendy; W T Carter | Zendy; S M Finegold | Zendy

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In vitro efficacy of sulbactam combined with ampicillin against anaerobic bacteria

Author(s) -

Hannah M. Wexler,

B Harris,

W T Carter,

S M Finegold

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.5.876

Subject(s) - ampicillin , sulbactam , bacteroides fragilis , microbiology and biotechnology , chloramphenicol , clindamycin , anaerobic bacteria , biology , antibiotics , fusobacterium , bacteria , bacteroides , antibiotic resistance , genetics , imipenem

An ampicillin-sulbactam combination was compared with ampicillin alone, chloramphenicol, clindamycin, and metronidazole against 272 strains of anaerobic bacteria. Chloramphenicol and ampicillin-sulbactam were the most effective, inhibiting 98 to 99% of strains tested at breakpoint (16 micrograms/ml). The combination of sulbactam and ampicillin was much more effective than ampicillin alone against Bacteroides fragilis strains but did not differ substantially from ampicillin alone against Fusobacterium spp., gram-positive rods, and gram-positive cocci.

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