In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester | Zendy

G S Kobayashi | Zendy; John R. Little | Zendy; Gerald Medoff | Zendy

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In vitro and in vivo comparisons of amphotericin B and N-D-ornithyl amphotericin B methyl ester

Author(s) -

G S Kobayashi,

John R. Little,

Gerald Medoff

Publication year - 1985

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.27.3.302

Subject(s) - amphotericin b , in vivo , in vitro , pharmacology , immunoadjuvant , toxicity , chemistry , microbiology and biotechnology , stereochemistry , biology , biochemistry , immunology , antifungal , immune system , organic chemistry

N-D-Ornithyl amphotericin B methyl ester (N-D-ornithyl AmE) has a lower toxicity for animals than does amphotericin B (AmB), and peak serum levels can be achieved that are fourfold higher than those obtained with an equivalent dose of AmB. However, N-D-ornithyl AmE has one-fourth the in vitro activity and between one-fifth and one-eighth the in vivo activity of AmB. N-D-ornithyl AmE and the corresponding lysyl derivative also lack the immunoadjuvant effects of AmB.

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