Penetration of ceftazidime into the cerebrospinal fluid of patients with and without evidence of meningeal inflammation | Zendy

I. W. Fong | Zendy; K B Tomkins | Zendy

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Penetration of ceftazidime into the cerebrospinal fluid of patients with and without evidence of meningeal inflammation

Author(s) -

I. W. Fong,

K B Tomkins

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.1.115

Subject(s) - ceftazidime , cerebrospinal fluid , meningitis , medicine , penetration (warfare) , bacterial meningitis , csf albumin , viral meningitis , anesthesia , surgery , biology , bacteria , pseudomonas aeruginosa , mathematics , genetics , operations research

The concentrations of ceftazidime in the serum and cerebrospinal fluid of patients with and without meningitis were measured at various times after a 2- or 3-g dose. At similar concentrations in serum, ceftazidime concentrations in cerebrospinal fluid at a given time were substantially lower in patients without meningitis (mean, 0.8 micrograms/ml) than in those with meningitis (mean, 22.6 micrograms/ml).

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