Open AccessRecovery of norfloxacin in feces after administration of a single oral dose to human volunteers
Author(s) -
RICHARD D. COFSKY,
L duBouchet,
Sheldon H. Landesman
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.1.110
Subject(s) - norfloxacin , feces , oral administration , oral dose , antibacterial agent , medicine , biology , pharmacology , antibiotics , microbiology and biotechnology , ciprofloxacin
Twelve healthy volunteers received single 400-mg oral doses of norfloxacin. During the ensuing 48 h, from 8.3 to 53.3% (mean, 28%) of this dose was recovered in the feces. Peak drug concentrations in fecal specimens ranged from 207 to 2,716 micrograms/g.
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