Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats | Zendy

J N Galgiani | Zendy; D B VanWyck | Zendy

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Ornithyl amphotericin methyl ester treatment of experimental candidiasis in rats

Author(s) -

J N Galgiani,

D B VanWyck

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.26.1.108

Subject(s) - amphotericin b , candida albicans , placebo , pharmacology , mycosis , medicine , antibiotics , chemistry , microbiology and biotechnology , antifungal , biology , immunology , pathology , alternative medicine

After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.

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