Open AccessOrnithyl amphotericin methyl ester treatment of experimental candidiasis in rats
Author(s) -
Johnn . Galgiani,
Davidb . Vanwyck
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.26.1.108
Subject(s) - amphotericin b , candida albicans , placebo , pharmacology , mycosis , medicine , antibiotics , chemistry , microbiology and biotechnology , antifungal , biology , immunology , pathology , alternative medicine
After intravenous Candida albicans infection, rats received orinthyl amphotericin methyl ester, amphotericin B, or diluent intravenously. At doses of 0.1 and 0.5 mg/kg, the drugs were equally effective in preventing deaths. However, at doses of 2.0 mg/kg, mortality after treatment with amphotericin B was greater than that after placebo, whereas orinthyl amphotericin methyl ester was fully protective.