Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B | Zendy

Claire Panosian | Zendy; Michael Barza | Zendy; Francis C. Szoka | Zendy; David J. Wyler | Zendy

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Treatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B

Author(s) -

Claire Panosian,

Michael Barza,

Francis C. Szoka,

David J. Wyler

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.25.5.655

Subject(s) - amphotericin b , cutaneous leishmaniasis , leishmania tropica , leishmaniasis , liposome , leishmania , inoculation , pharmacology , ratón , leishmania major , leishmania mexicana , immunology , antifungal , medicine , microbiology and biotechnology , parasite hosting , biology , biochemistry , world wide web , computer science

The therapeutic efficacy of a liposomal preparation of amphotericin B was evaluated in two murine models of cutaneous leishmaniasis. No significant decrease in tissue parasite density was observed in C57BL/6 mice after systemic treatment instituted seven days after footpad inoculation with Leishmania tropica; in contrast, BALB/c mice showed a modest response.

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