Open AccessTreatment of experimental cutaneous leishmaniasis with liposome-intercalated amphotericin B
Author(s) -
Claire Panosian,
Michael Barza,
Francis C. Szoka,
David J. Wyler
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.25.5.655
Subject(s) - amphotericin b , cutaneous leishmaniasis , leishmania tropica , leishmaniasis , liposome , leishmania , pharmacology , inoculation , ratón , leishmania mexicana , medicine , immunology , leishmania major , antifungal , parasite hosting , biology , microbiology and biotechnology , biochemistry , world wide web , computer science
The therapeutic efficacy of a liposomal preparation of amphotericin B was evaluated in two murine models of cutaneous leishmaniasis. No significant decrease in tissue parasite density was observed in C57BL/6 mice after systemic treatment instituted seven days after footpad inoculation with Leishmania tropica; in contrast, BALB/c mice showed a modest response.