Ceftazidime nephrotoxicity in rats | Zendy

Friedrich C. Luft | Zendy; D W Visscher | Zendy; D.M. Nierste | Zendy; D K Blase | Zendy; N Walker | Zendy; George R. Aronoff | Zendy

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Ceftazidime nephrotoxicity in rats

Author(s) -

Friedrich C. Luft,

D W Visscher,

D.M. Nierste,

D K Blase,

N Walker,

George R. Aronoff

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.25.4.513

Subject(s) - ceftazidime , nephrotoxicity , tobramycin , cefazolin , cephaloridine , medicine , pharmacology , antibiotics , chemistry , cephalosporin , kidney , gentamicin , biology , biochemistry , bacteria , genetics , pseudomonas aeruginosa

The nephrotoxicity of ceftazidime compared with that of cefazolin or cephaloridine and the capacity of ceftazidime to enhance the nephrotoxicity of tobramycin were evaluated in rats. Only cephaloridine and tobramycin given alone altered creatinine clearance or caused significant histological injury. Our data suggest that ceftazidime is no more nephrotoxic than cefazolin and does not enhance the nephrotoxicity of tobramycin.

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