Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin | Zendy

L E Bryan | Zendy; Samantha Kwan | Zendy; A J Godfrey | Zendy

Open Access

Resistance of Pseudomonas aeruginosa mutants with altered control of chromosomal beta-lactamase to piperacillin, ceftazidime, and cefsulodin

Author(s) -

L E Bryan,

Samantha Kwan,

A J Godfrey

Publication year - 1984

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.25.3.382

Subject(s) - cefsulodin , piperacillin , ceftazidime , pseudomonas aeruginosa , microbiology and biotechnology , beta lactamase , mutant , biology , bacteria , genetics , escherichia coli , gene

Examination of beta-lactam susceptibility of mutants altered in the control of chromosomal beta-lactamase of Pseudomonas aeruginosa supports the view that a constitutive level of beta-lactamase is not an adequate explanation for resistance to cefsulodin and ceftazidime but could be for resistance to piperacillin which has an efficiency of hydrolysis ca. 10 times higher than does cefsulodin or ceftazidime.

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