Open AccessProduction of hypoprothrombinemia by moxalactam and 1-methyl-5-thiotetrazole in rats
Author(s) -
James J. Lipsky,
J.C. Lewis,
W J Novick
Publication year - 1984
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.25.3.380
Subject(s) - moxalactam , hypoprothrombinemia , latamoxef , cefotaxime , prothrombin time , mtt assay , medicine , antibiotics , cephalosporin , chemistry , biochemistry , vitamin k , in vitro
To determine whether the hypoprothrombinemia associated with antibiotics containing a 1-methyl-5-thiotetrazole (MTT) group is a result of the presence of the MTT group, rats were maintained on a vitamin K-deficient diet for 10 days and then received either intravenous moxalactam or cefotaxime or oral MTT for two additional days. MTT and moxalactam, which contains the MTT group, prolonged prothrombin time. Cefotaxime, which lacks the MTT group, had no effect.
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