Pharmacokinetics of metronidazole in patients undergoing peritoneal dialysis | Zendy

John Cassey | Zendy; Dean Clark | Zendy; Pamela M. Merrick | Zendy; Bernard F. Jones | Zendy

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Pharmacokinetics of metronidazole in patients undergoing peritoneal dialysis

Author(s) -

John Cassey,

Dean Clark,

Pamela M. Merrick,

Bernard F. Jones

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.6.950

Subject(s) - metronidazole , peritoneal dialysis , medicine , pharmacokinetics , dialysis , urology , antibiotics , surgery , chemistry , biochemistry

After a single 500-mg intravenous dose of metronidazole, plasma and dialysate levels were measured over a 7.5-h period in five patients undergoing peritoneal dialysis for terminal renal failure. Approximately 10% of this dose was removed by dialysis during that period, and therapeutic levels were maintained in plasma. No routine adjustment in the dosage of metronidazole appears necessary in patients undergoing peritoneal dialysis.

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