Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity | Zendy

C. Shipman | Zendy; Shiyuan Tong | Zendy; Sandra H. Smith | Zendy; Namat Bashir Katlama | Zendy; John C. Drach | Zendy

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Establishment of a murine cell line resistant to arabinosyladenine and devoid of adenosine deaminase activity

Author(s) -

C. Shipman,

Shiyuan Tong,

Sandra H. Smith,

Namat Bashir Katlama,

John C. Drach

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.6.947

Subject(s) - adenosine deaminase , adenosine kinase , adenosine , cell culture , population , biology , substrate specificity , microbiology and biotechnology , chemistry , enzyme , biochemistry , medicine , genetics , environmental health

A population of cells stably resistant to a concentration of arabinosyladenine 100-fold greater than that tolerated by wild-type cells was selected over a period of 15 months. The cells are not cross resistant to arabinosylcytosine and may have at least one kinase with altered substrate specificity.

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