Open AccessOral antiviral drugs in experimental herpes simplex keratitis
Author(s) -
Herbert E. Kaufman,
Emily D. Varnell,
Ysolina M. Centifanto-Fitzgerald,
Erik De Clercq,
Grace E. Kissling
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.24.6.888
Subject(s) - keratitis , tears , herpes simplex virus , medicine , virology , idoxuridine , virus , aciclovir , oral administration , disease , herpesviridae , simplexvirus , viral shedding , deoxyuridine , viral disease , dermatology , immunology , biology , pharmacology , pathology , dna , genetics
Chronic oral administration of acyclovir or bromovinyl deoxyuridine to rabbits did not prevent recurrence of virus shedding or clinical corneal disease, nor did it alter the clinical course of recurrences of ocular herpetic disease or result in the appearance of resistant virus in tears.