Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides | Zendy

Myles E. Gombert | Zendy; T M Aulicino | Zendy

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Synergism of imipenem and amikacin in combination with other antibiotics against Nocardia asteroides

Author(s) -

Myles E. Gombert,

T M Aulicino

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.5.810

Subject(s) - imipenem , amikacin , cefotaxime , nocardia , trimethoprim , sulfamethoxazole , microbiology and biotechnology , antibiotics , antibacterial agent , agar dilution , medicine , chemistry , biology , minimum inhibitory concentration , bacteria , antibiotic resistance , genetics

The in vitro activities of imipenem (formerly imipemide, N-formimidoyl thienamycin, or MK0787) and amikacin in combination with cefotaxime, trimethoprim-sulfamethoxazole, and each other were tested against 26 Nocardia asteroides strains. The agar dilution method was used for all tests. Synergy was present in 80% of tests with imipenem-trimethoprim-sulfamethoxazole, in 92% of tests with imipenem-cefotaxime, and in 83% of tests with amikacin-trimethoprim-sulfamethoxazole. Indifference was found on rare occasions, and no antagonism was seen.

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