Open AccessEffects of (E)-5-(2-bromovinyl)-2'-deoxyuridine on proliferation of human fibroblasts, peripheral blood mononuclear cells, and granulocyte-monocyte progenitor cells in vitro
Author(s) -
Alec E. Wittek,
Pamela S. Cohen,
Ann M. Arvin,
S. D. Smith,
Celine M. Koropchak,
Erik De Clercq
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.24.5.803
Subject(s) - peripheral blood mononuclear cell , deoxyuridine , monocyte , progenitor cell , in vitro , granulocyte , microbiology and biotechnology , immunology , chemistry , biology , pharmacology , biochemistry , stem cell , dna
Inhibition of human fibroblasts, granulocyte-monocyte progenitor cells, and lymphocytes was observed at (E)-5-(2-bromovinyl)-2'-deoxyuridine concentrations ranging from 21 to 197 micrograms/ml. These concentrations were 10- to 100-fold above usual serum concentrations after oral administration. (E)-5-(2-Bromovinyl)-2'-deoxyuridine compares favorably with currently used antivirals in terms of in vitro myelotoxicity and immunotoxicity.