Pharmacokinetics and tissue penetration of ciprofloxacin | Zendy

B J Crump | Zendy; Robert A. Wise | Zendy; J Dent | Zendy

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Pharmacokinetics and tissue penetration of ciprofloxacin

Author(s) -

B J Crump,

Robert A. Wise,

J Dent

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.5.784

Subject(s) - pharmacokinetics , ciprofloxacin , penetration (warfare) , antibacterial agent , pharmacology , absorption (acoustics) , medicine , half life , oral administration , antibiotics , chemistry , materials science , biochemistry , composite material , operations research , engineering

A 500-mg dose of the quinoline ciprofloxacin was administered orally to each of six healthy male volunteers, after which the concentrations of this agent in serum and blister fluid were measured. Absorption appeared to be rapid, with a mean peak level of 2.4 micrograms/ml attained 1.25 h after administration. The serum elimination half-life was 3.9 h. The agent penetrated blister fluid well, the percent penetration being 57%. Urinary recovery of ciprofloxacin was 30%.

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