Open AccessBacteriostatic and fungostatic action of catecholamide iron chelators
Author(s) -
Raymond J. Bergeron,
Gary T. Elliott,
Steven J. Kline,
Reuben Ramphal,
LaToya James
Publication year - 1983
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.24.5.725
Subject(s) - candida albicans , escherichia coli , siderophore , staphylococcus aureus , catechol , chemistry , spermidine , microbiology and biotechnology , chelation , in vitro , pseudomonas aeruginosa , biochemistry , bacteria , mechanism of action , bacterial growth , growth inhibition , biology , enzyme , organic chemistry , genetics , gene
Iron starvation as a means of controlling the proliferation of microorganisms was evaluated in vitro with spermidine catecholamide iron chelators. The growth of Escherichia coli and Pseudomonas aeruginosa was sensitive only to (D,L)-parabactin, whereas the growth of Candida albicans and Staphylococcus aureus was sensitive to a variety of catecholamide chelators. The disappearance of catecholamide activity upon methylation of the catechol hydroxyls, as well as iron reversal experiments, strongly suggests that the mechanism by which these compounds suppress growth is dependent upon their ability to sequester iron.