Antibacterial activity of norfloxacin in the gastrointestinal tracts of rats | Zendy

Poul C. FrimodtMøller | Zendy; Klaus MøllerErnst Jensen | Zendy; Paul O. Madsen | Zendy

AI Assistant Blog Pricing

Home ZAIA Blog

Open Access

Antibacterial activity of norfloxacin in the gastrointestinal tracts of rats

Author(s) -

Poul C. FrimodtMøller,

Klaus MøllerErnst Jensen,

Paul O. Madsen

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.4.560

Subject(s) - norfloxacin , neomycin , bacteria , anaerobic bacteria , microbiology and biotechnology , antibiotics , antibacterial agent , biology , pharmacology , ciprofloxacin , genetics

The capacities of norfloxacin (MK-0366) and neomycin to reduce the numbers of bacteria in the gastrointestinal tracts of rats were evaluated. Results of a 3-day treatment with norfloxacin were compared with those of a 3-day treatment with neomycin. Both drugs significantly decreased gram-negative and gram-positive bacteria. Norfloxacin effected a significantly greater reduction in numbers of gram-negative bacteria than did neomycin. Norfloxacin also significantly increased the number of anaerobic bacteria. Although neomycin reduced gram-positive bacteria more effectively than did norfloxacin, this difference between the two drugs was not significant. Norfloxacin merits further study for potential as a bowel sterilant.

The content you want is available to Zendy users.

Already have an account? Click here to sign in.

Having issues? You can contact us here

Accelerating Research