Stability of gentamicin, tobramycin, and amikacin in combination with four beta-lactam antibiotics | Zendy

Richard H. Glew | Zendy; R A Pavuk | Zendy

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Stability of gentamicin, tobramycin, and amikacin in combination with four beta-lactam antibiotics

Author(s) -

Richard H. Glew,

R A Pavuk

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.4.474

Subject(s) - tobramycin , carbenicillin , amikacin , piperacillin , moxalactam , aminoglycoside , gentamicin , cefotaxime , microbiology and biotechnology , antibiotics , chemistry , medicine , biology , pseudomonas aeruginosa , bacteria , genetics

The stability of the aminoglycosides gentamicin, tobramycin, and amikacin stored in combination with carbenicillin, piperacillin, cefotaxime, and moxalactam was evaluated at four temperatures (25, 4, -8, and -70 degrees C) over a 3-week period. Amikacin was the most stable of the aminoglycosides and demonstrated no loss of activity when stored with either carbenicillin or piperacillin. Gentamicin and tobramycin were inactivated by carbenicillin and piperacillin at 25 and 4 degrees C, with aminoglycoside activity declining substantially after 8 to 48 h of storage; virtually no loss of gentamicin or tobramycin activity occurred with storage at -8 or -70 degrees C. Cefotaxime and moxalactam produced no degradation of any of the three aminoglycosides.

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