Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia | Zendy

Walter T. Hughes | Zendy; B L Smith | Zendy

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Intermittent chemoprophylaxis for Pneumocystis carinii pneumonia

Author(s) -

Walter T. Hughes,

B L Smith

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.2.300

Subject(s) - pneumocystis carinii , chemoprophylaxis , trimethoprim , pneumonia , sulfamethoxazole , medicine , regimen , corticosteroid , respiratory disease , immunology , antibiotics , microbiology and biotechnology , biology , pneumocystis jirovecii , lung

An intermittent regimen of trimethoprim-sulfamethoxazole was tested in the corticosteroid-treated rat model to learn whether or not administration for 3 consecutive days a week would provide prophylaxis equal to continuous daily doses. Although all of the untreated control animals acquired Pneumocystis carinii pneumonia, none of the animals given either continuous or intermittent trimethoprim-sulfamethoxazole became infected.

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