Effect of inoculum size on Haemophilus influenzae type b susceptibility to new and conventional antibiotics | Zendy

Craig A. Laferrière | Zendy; Melvin I. Marks | Zendy; David Welch | Zendy

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Effect of inoculum size on Haemophilus influenzae type b susceptibility to new and conventional antibiotics

Author(s) -

Craig A. Laferrière,

Melvin I. Marks,

David Welch

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.2.287

Subject(s) - microbiology and biotechnology , haemophilus influenzae , antibiotics , ampicillin , chloramphenicol , ceftriaxone , haemophilus , penicillin , agar dilution , biology , pasteurellaceae , bacteria , minimum inhibitory concentration , genetics

Thirty-three Haemophilus influenzae type b isolates, including beta-lactamase acetyltransferase-positive strains, were tested by microtiter broth dilution for susceptibility to eight beta-lactam compounds and chloramphenicol. All antibiotics except ampicillin and chloramphenicol were highly bactericidal against all isolates at an inoculum of 10(5) CFU/ml. However, at an inoculum of 10(5) CFU/ml, the minimal bactericidal concentrations of all drugs except ceftriaxone were above levels usually achievable in cerebrospinal fluid. Results of time-kill studies confirmed this inoculum effect. In vivo studies are needed to test the clinical impact of these observations.

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