Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis | Zendy

J Modaï | Zendy; Daniel Vittecoq | Zendy; J.M. Decazes | Zendy; Michel Wolff | Zendy; A. Meulemans | Zendy

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Penetration of ceftazidime into cerebrospinal fluid of patients with bacterial meningitis

Author(s) -

J Modaï,

Daniel Vittecoq,

J.M. Decazes,

Michel Wolff,

A. Meulemans

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.24.1.126

Subject(s) - ceftazidime , cerebrospinal fluid , meningitis , antibiotics , medicine , bacterial meningitis , penetration (warfare) , pharmacokinetics , antibacterial agent , chromatography , anesthesia , chemistry , microbiology and biotechnology , surgery , biology , bacteria , pseudomonas aeruginosa , mathematics , genetics , operations research

Four 2-g doses of ceftazidime were infused intravenously over 30 min at 8-h intervals, first between days 2 and 4 and again between days 11 and 20, in 11 patients with bacterial meningitis undergoing treatment with other antibiotics. Concentrations of ceftazidime in serum and cerebrospinal fluid samples obtained 120 or 180 min after dose 4 were measured by high-pressure liquid chromatography. Concentrations in cerebrospinal fluid ranged from 2 to 30 micrograms/ml, depending on the sampling time and the time elapsed since the onset of the disease.

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