Pharmacology of ketoconazole suspension in infants and children | Zendy

Charles M. Ginsburg | Zendy; George H. McCracken | Zendy; Kent Olsen | Zendy

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Pharmacology of ketoconazole suspension in infants and children

Author(s) -

Charles M. Ginsburg,

George H. McCracken,

Kent Olsen

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.5.787

Subject(s) - ketoconazole , pharmacokinetics , suspension (topology) , plasma concentration , pharmacology , chemistry , medicine , chromatography , antifungal , dermatology , mathematics , homotopy , pure mathematics

The pharmacokinetics of ketoconazole administered as either a commercially prepared suspension or as a crushed tablet in applesauce were studied in 12 children. The mean peak plasma concentration of ketoconazole and the area under the plasma time-concentration curve were approximately twofold greater with the suspension than with the crushed tablets.

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