Comparative activity of amantadine and ribavirin against influenza virus in vitro: possible clinical relevance | Zendy

Michael Browne | Zendy; Martin Moss | Zendy; M R Boyd | Zendy

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Comparative activity of amantadine and ribavirin against influenza virus in vitro: possible clinical relevance

Author(s) -

Michael Browne,

Martin Moss,

M R Boyd

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.3.503

Subject(s) - amantadine , ribavirin , virology , in vitro , multiplicity of infection , virus , orthomyxoviridae , multiplicity (mathematics) , medicine , influenza a virus , biology , hepatitis c virus , biochemistry , mathematical analysis , mathematics

The activities of amantadine and ribavirin against influenza A viruses were compared against low-multiplicity (plaque inhibition) and high-multiplicity (protein synthesis inhibition) infections. Our results suggest that the predictive value of in vitro data for the clinic may be improved by consideration of tests against a high-multiplicity infection.

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