Comparative in vitro activity of Sch 29,482, a new oral penem, against Neisseria gonorrhoeae | Zendy

M Y Khan | Zendy; R P Gruninger | Zendy; S.M. Nelson | Zendy; Maggie Simpson | Zendy

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Comparative in vitro activity of Sch 29,482, a new oral penem, against Neisseria gonorrhoeae

Author(s) -

M Y Khan,

R P Gruninger,

S.M. Nelson,

Maggie Simpson

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.3.481

Subject(s) - neisseria gonorrhoeae , norfloxacin , antimicrobial , ampicillin , microbiology and biotechnology , tetracycline , erythromycin , in vitro , cephalosporin , antibiotics , chemistry , penicillin , antibacterial agent , biology , ciprofloxacin , biochemistry

The in vitro activity of Sch 29,482, a new oral beta-lactam antimicrobial agent, was compared with those of norfloxacin, rosoxacin, ampicillin, erythromycin, and tetracycline against 142 Neisseria gonorrhoeae strains. Sch 29,482 was as active as norfloxacin and rosoxacin. Its activity was greater than the other three antimicrobial agents. It inhibited 90% of the isolates, regardless of beta-lactamase activity, at a concentration of less than or equal to 0.06 micrograms/ml.

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