Gentamicin persistence in rat endolymph and perilymph after a two-day constant infusion | Zendy

Patrice Tran Ba Huy | Zendy; A. Meulemans | Zendy; Medhat R. Wassef | Zendy; C Manuel | Zendy; Olivier Sterkers | Zendy; Catherine Amiel | Zendy

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Gentamicin persistence in rat endolymph and perilymph after a two-day constant infusion

Author(s) -

Patrice Tran Ba Huy,

A. Meulemans,

Medhat R. Wassef,

C Manuel,

Olivier Sterkers,

Catherine Amiel

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.2.344

Subject(s) - perilymph , endolymph , gentamicin , aminoglycoside , clearance , inner ear , chemistry , pharmacokinetics , persistence (discontinuity) , medicine , anesthesia , endocrinology , anatomy , antibiotics , biochemistry , urology , geotechnical engineering , engineering

The kinetics of gentamicin in the inner ear fluids of rats were studied up to 15 days after cessation of a 2-day constant infusion of 10 micrograms/min. In endolymph, the concentration of gentamicin persisted at about 1 microgram/ml for up to 15 days, precluding the determination of the half-life of the drug in this fluid. In perilymph, gentamicin cleared more slowly than after a shorter period of infusion. These results suggest that the tissues of the inner ear could bind the aminoglycoside and then slowly release it into the surrounding fluids.

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