Rapid selection of organisms with increasing resistance on subinhibitory concentrations of norfloxacin in agar | Zendy

James H. Tenney | Zendy; R W Maack | Zendy; G R Chippendale | Zendy

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Rapid selection of organisms with increasing resistance on subinhibitory concentrations of norfloxacin in agar

Author(s) -

James H. Tenney,

R W Maack,

G R Chippendale

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.1.188

Subject(s) - norfloxacin , nalidixic acid , microbiology and biotechnology , escherichia coli , agar , pseudomonas aeruginosa , biology , antibacterial agent , minimum inhibitory concentration , enterobacteriaceae , antibiotics , ciprofloxacin , bacteria , biochemistry , genetics , gene

Serial passage of Pseudomonas aeruginosa ATCC 27853 or Escherichia coli ATCC 25922 on agar with subinhibitory concentrations of norfloxacin rapidly produced isolates with minimal inhibitory concentrations (MICs) of norfloxacin up to 512-fold higher than that for the original strain. Although MICs of seven unrelated antibiotics were unchanged, increasing MICs occurred in parallel with norfloxacin, cinoxacin, and nalidixic acid regardless of which of these three organic acids was used to select for increased resistance. P. aeruginosa with a norfloxacin MIC of greater than 256 micrograms/ml could be selected; however, E. coli with MICs greater than the clinically achievable level of 16 micrograms/ml could not be produced.

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