Toxicity of amphotericin B, miconazole, and ketoconazole to human granulocyte progenitor cells in vitro | Zendy

T C Meeker | Zendy; Martin Siegel | Zendy; F M Shiota | Zendy; James J. Crowley | Zendy; Robert W. McGuffin | Zendy

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Toxicity of amphotericin B, miconazole, and ketoconazole to human granulocyte progenitor cells in vitro

Author(s) -

T C Meeker,

Martin Siegel,

F M Shiota,

James J. Crowley,

Robert W. McGuffin

Publication year - 1983

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.23.1.169

Subject(s) - ketoconazole , miconazole , amphotericin b , progenitor cell , pharmacology , toxicity , in vitro , granulocyte , biology , medicine , microbiology and biotechnology , immunology , antifungal , stem cell , biochemistry , genetics

Granulocyte progenitor cells were grown in culture with amphotericin B, miconazole, and ketoconazole. Significant suppression of progenitor cell growth could be demonstrated with all three drugs at increasing concentrations. No additive suppression was seen when amphotericin B and ketoconazole were combined.

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