Open AccessConversion of amoscanate to a mutagenic metabolite in gnotobiotic mice implanted with Streptococcus equinus
Author(s) -
Bandaru S. Reddy,
Robert P. Batzinger,
Christopher J. Molineaux,
Ernest Bueding
Publication year - 1982
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.22.4.707
Subject(s) - mutagen , metabolite , in vivo , bacteria , streptococcus , microbiology and biotechnology , biology , in vitro , small intestine , antibiotics , pharmacology , carcinogen , biochemistry , genetics
Recent in vitro studies indicate that intestinal bacteria convert amoscanate (4-nitro-4'-isothiocyanodiphenylamine), an antischistosomal drug, to a potent mutagen. The present study indicates that the implantation of germfree mice with Streptococcus equinus, isolated from the small intestine of conventional mice, restores the mutagenic activation of amoscanate in vivo.