Synergy of fosmidomycin (FR-31564) and other antimicrobial agents | Zendy

H. C. Neu | Zendy; Takuya Kamimura | Zendy

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Synergy of fosmidomycin (FR-31564) and other antimicrobial agents

Author(s) -

H. C. Neu,

Takuya Kamimura

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.4.560

Subject(s) - ticarcillin , carbenicillin , cefazolin , gentamicin , microbiology and biotechnology , ampicillin , antimicrobial , biology , antibiotics , antibiotic resistance , imipenem

Fosmidomycin (FR-31564), a phosphonic acid derivative, was combined with cefazolin, cephalexin, ampicillin, carbenicillin, ticarcillin, gentamicin, and trimethoprim. Synergy between fosmidomycin and penicillins or cephalosporins was found for 37 to 52% of the Enterobacteriaceae tested. Synergy with trimethoprim was found against 55% of bacteria isolated, but only 17% of the strains showed synergy between formidomycin and gentamicin. Synergy between fosmidomycin and ticarcillin was shown for 35% of the Pseudomonas isolates. Cefazolin-, ampicillin-, and gentamicin-resistant isolates of various species were synergistically inhibited by fosmidomycin, as were ticarcillin- and gentamicin-resistant isolates. Antagonism was not encountered. This study illustrates another example of synergistic activity of compounds which attack different mechanisms in bacterial cells.

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