Synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam | Zendy

Harold C. Neu | Zendy

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Synergistic activity of mecillinam in combination with the beta-lactamase inhibitors clavulanic acid and sulbactam

Author(s) -

Harold C. Neu

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.3.518

Subject(s) - mecillinam , sulbactam , clavulanic acid , microbiology and biotechnology , providencia , morganella morganii , citrobacter , enterobacter , enterobacter cloacae , proteus mirabilis , klebsiella , beta lactamase , chemistry , biology , enterobacteriaceae , escherichia coli , antibiotics , biochemistry , amoxicillin , antibiotic resistance , imipenem , gene

The beta-lactamase inhibitors clavulanic acid and sulbactam were combined with mecillinam. beta-Lactamase-containing Escherichia coli resistant to mecillinam was synergistically inhibited by both clavulanic acid and sulbactam. beta-Lactamase-containing Enterobacter was synergistically inhibited, but strains lacking beta-lactamases were not synergistically inhibited. Synergistic inhibition was noted for beta-lactamase-containing, mecillinam-resistant Klebsiella, Citrobacter, Serratia, and Salmonella isolates, but only 18% of beta-lactamase-containing Proteus mirabilis, Providencia rettgeri, Providencia stuartii, and Morganella morganii were synergistically inhibited by the combinations.

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