Ampicillin susceptibility and ampicillin-induced killing rate of Escherichia coli | Zendy

Iwan P. Thonus | Zendy; P Fontijne | Zendy; M F Michel | Zendy

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Ampicillin susceptibility and ampicillin-induced killing rate of Escherichia coli

Author(s) -

Iwan P. Thonus,

P Fontijne,

M F Michel

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.3.386

Subject(s) - ampicillin , escherichia coli , minimum inhibitory concentration , agar dilution method , dilution , amp resistance , microbiology and biotechnology , chemistry , agar dilution , agar , chromatography , biology , antibiotics , bacteria , biochemistry , genetics , physics , thermodynamics , gene

The killing rate induced by ampicillin was determined in 20 strains of Escherichia coli. The apparent generation rate constant for each E. coli showed a characteristic concentration-dependent course. This course can be mathematically described and is determined by four parameters. Three of these parameters determine the speed of the process, and the fourth parameter determines a minimal concentration. The susceptibility of the strains, measured as the minimal inhibitory concentration by an agar dilution method, correlated with the minimal concentration and with a minimal inhibitory concentration calculated from the curve, but not with the rate-determining parameters.

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