Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica | Zendy

Frances D. Gillin | Zendy; David S. Reiner | Zendy; M Suffness | Zendy

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Bruceantin, a potent amoebicide from a plant, Brucea antidysenterica

Author(s) -

Frances D. Gillin,

David S. Reiner,

M Suffness

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.2.342

Subject(s) - entamoeba histolytica , traditional medicine , in vitro , dysentery , ic50 , microgram , biology , chemistry , microbiology and biotechnology , medicine , biochemistry

Bruceantin, purified from an Ethiopian plant used to treat dysentery, killed Entamoeba histolytica in vitro (IC50 [the concentration of drug which decreased the number of colonies to half that of controls] = 0.018 microgram/ml). Six related quassinoids of 17 tested were also amoebicidal. No relationship between quassinoid structure and amoebicidal activity was apparent.

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