In vitro activity of antibiotics commonly used in the treatment of otitis media against Streptococcus pneumoniae isolates with different susceptibilities to penicillin | Zendy

Martha Tarpay | Zendy; David Welch | Zendy; Hamid Salari | Zendy; Melvin I. Marks | Zendy

Open Access

In vitro activity of antibiotics commonly used in the treatment of otitis media against Streptococcus pneumoniae isolates with different susceptibilities to penicillin

Author(s) -

Martha Tarpay,

David Welch,

Hamid Salari,

Melvin I. Marks

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.22.1.145

Subject(s) - streptococcus pneumoniae , sulfisoxazole , microbiology and biotechnology , erythromycin , otitis , penicillin , trimethoprim , antibiotics , sulfamethoxazole , medicine , antibacterial agent , biology , tetracycline , surgery

Susceptibilities of 82 clinical isolates of Streptococcus pneumoniae, including 25 from the middle-ear fluid, were evaluated against antibiotics commonly used in the treatment of acute otitis media. Potentially significant resistance occurred in 6% of the isolates to erythromycin and an erythromycin-sulfisoxazole combination. The combination of trimethoprim and sulfamethoxazole was synergistic for 95% of the isolates. Only 2.5% of all of the isolates were resistant to both erythromycin-sulfisoxazole and trimethoprim-sulfamethoxazole. The presently used drug regimens should be effective against the majority of S. pneumoniae isolates in otitis media.

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