Mutational Enzymatic Resistance of Enterobacter Species to Beta-Lactam Antibiotics | Zendy

Mary F. Lampe | Zendy; Barbara J. Allan | Zendy; Barbara H. Minshew | Zendy; John C. Sherris | Zendy

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Mutational Enzymatic Resistance of Enterobacter Species to Beta-Lactam Antibiotics

Author(s) -

Mary F. Lampe,

Barbara J. Allan,

Barbara H. Minshew,

John C. Sherris

Publication year - 1982

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.21.4.655

Subject(s) - enterobacter aerogenes , enterobacter cloacae , mutant , microbiology and biotechnology , enterobacter , biology , antibiotics , enterobacteriaceae , enzyme , bacteria , biochemistry , gene , escherichia coli , genetics

Mutants with enhanced beta-lactam resistance were selected from strains of Enterobacter cloacae and E. aerogenes by using three antibiotics. High-level beta-lactamase-producing mutants had similar degrees of increased resistance, enzyme substrate profiles, and isoelectric (pI) values irrespective of the selective agent. Reverse mutants from a resistant E. cloacae mutant regained the susceptibility pattern originally exhibited by the wild type, or were of enhanced susceptibility, and no longer expressed increased beta-lactamase production. beta-Lactamases of the mutants were similar in pI values to the wild-type enzyme. The increased resistance of the mutants therefore appeared to be accounted for by increased beta-lactamase production.

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