Dose-Ranging Study of Ceftriaxone for Uncomplicated Gonorrhea in Men | Zendy

H. Hunter Handsfield | Zendy; Victory L. Murphy | Zendy; King K. Holmes | Zendy

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Dose-Ranging Study of Ceftriaxone for Uncomplicated Gonorrhea in Men

Author(s) -

H. Hunter Handsfield,

Victory L. Murphy,

King K. Holmes

Publication year - 1981

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.20.6.839

Subject(s) - ceftriaxone , gonorrhea , medicine , toxicity , antibiotics , dose ranging study , neisseria gonorrhoeae , antibacterial agent , intramuscular injection , gastroenterology , pharmacology , microbiology and biotechnology , biology , immunology , pathology , double blind , alternative medicine , human immunodeficiency virus (hiv) , placebo

Uncomplicated gonorrhea in men was successfully treated with ceftriaxone in single intramuscular doses of 125 mg (15 patients), 250 mg (16 patients), or 500 mg (15 patients). All 45 pretreatment gonococcal isolates tested were inhibited by </=0.016 mug of ceftriaxone per ml. Treatment was well tolerated and caused no toxicity.

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