Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin | Zendy

Reinaldo Martinelli | Zendy; Andréia Aparecida Ferreira Lopes | Zendy; Márcio Moysés de Oliveira | Zendy; Heonir Rocha | Zendy

Open Access

Amoxicillin-clavulanic acid in treatment of urinary tract infection due to gram-negative bacteria resistant to penicillin

Author(s) -

Reinaldo Martinelli,

Andréia Aparecida Ferreira Lopes,

Márcio Moysés de Oliveira,

Heonir Rocha

Publication year - 1981

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.20.6.800

Subject(s) - amoxicillin , clavulanic acid , penicillin , urinary system , medicine , microbiology and biotechnology , amoxicillin/clavulanic acid , antibiotics , bacteria , antibacterial agent , gastroenterology , biology , genetics

Twenty-two adult patients with urinary tract infections caused by penicillin-resistant bacteria completed treatment with amoxicillin alone or amoxicillin plus clavulanic acid in a randomized double-blind clinical trial. Of the 13 patients treated with amoxicillin plus clavulanic acid, the absence of bacteriuria within 7 days of therapy was observed in 85%, as compared with only 25% of the 8 patients receiving amoxicillin only. There were no significant side effects nor any clinical, biochemical, or hematological abnormalities related to either treatment. It was concluded that the combination of clavulanic acid and amoxicillin could be useful in the treatment of uncomplicated urinary tract infection caused by penicillin-resistant bacteria.

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