Pharmacokinetics of moxalactam in patients with renal failure and during hemodialysis | Zendy

Subramani Srinivasan | Zendy; Harold C. Neu | Zendy

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Pharmacokinetics of moxalactam in patients with renal failure and during hemodialysis

Author(s) -

Subramani Srinivasan,

Harold C. Neu

Publication year - 1981

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.20.3.398

Subject(s) - moxalactam , hemodialysis , pharmacokinetics , medicine , dialysis , half life , pharmacology , urology , antibiotics , cephalosporin , biology , microbiology and biotechnology

The pharmacokinetics of moxalactam were determined in eight patients with end stage renal disease who were undergoing chronic hemodialysis. The mean half-life of moxalactam in the interdialysis period was 19 h, with a range of 9 to 30 h. The mean half-life of moxalactam during dialysis was 4 +/- 0.58 h. Serum levels of 30 +/- 10 micrograms/ml were present 24 h after a 1-g dose in the interdialysis period. A dose of 1 g at the end of each dialysis period in patients undergoing thrice-weekly hemodialysis would provide levels far in excess of the minimal inhibitory levels against Enterobacteriaceae.

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