Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa | Zendy

Kyoko Yamashita | Zendy; H Kawabe | Zendy; S Mitsuhashi | Zendy

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Synergistic activities of fortimicin A and beta-lactam antibiotics against Pseudomonas aeruginosa

Author(s) -

Kyoko Yamashita,

H Kawabe,

S Mitsuhashi

Publication year - 1981

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.20.1.33

Subject(s) - carbenicillin , pseudomonas aeruginosa , piperacillin , gentamicin , microbiology and biotechnology , antibiotics , minimum inhibitory concentration , aminoglycoside , biology , antibacterial agent , chemistry , bacteria , genetics

The inhibitory and bactericidal activities of fortimicin A (FTM-A) alone against Pseudomonas aeruginosa were compared with those of FTM-A in combination with beta-lactam antibiotics. As tested by the checkerboard method, most beta-lactam antibiotics tested had synergistic effects on the inhibitory activity of FTM-A against one strain of P. aeruginosa. Addition of a sublethal concentration of carbenicillin resulted in a significant increase in the rate of bacterial killing of FTM-A against P. aeruginosa. The antibacterial activity of FTM-A against 50 gentamicin-susceptible and 50 gentamicin-resistant clinical isolates of P. aeruginosa was clearly enhanced by addition of a subinhibitory concentration of carbenicillin or piperacillin.

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