Open AccessSilver Sulfadiazine: Interaction with Isolated Deoxyribonucleic Acid
Author(s) -
Herbert S. Rosenkranz,
Samuel Rosenkranz
Publication year - 1972
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.2.5.373
Subject(s) - sulfadiazine , dna , silver sulfadiazine , intercalation (chemistry) , moiety , silver nitrate , chemistry , biochemistry , stereochemistry , biology , inorganic chemistry , nuclear chemistry , antibiotics , genetics , wound healing
Silver sulfadiazine (AgSu) was found to interact withisolated deoxyribonucleic acid (DNA) to form nondissociable complexes. These complexes differ in physical and chemical properties from those that are established when silver nitrate is added to DNA. The reaction between AgSu and DNA is visualized as occurring in two stages: (i) a weak and reversible interaction (intercalation) between DNA and the sulfadiazine moiety and (ii) a tight binding involving the silver atom. In the first stage, sodium sulfadiazine competes with AgSu for the DNA.