Open AccessSusceptibility of Mycobacteria to Rifampin
Author(s) -
Charles L. Woodley,
James O. Kilburn,
Hugo L. David,
Vella A. Silcox
Publication year - 1972
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.2.4.245
Subject(s) - mycobacterium kansasii , microbiology and biotechnology , mycobacterium marinum , tuberculosis , antibiotics , biology , mycobacterium , mycobacterium tuberculosis , bacteria , rifampicin , antibiotic resistance , medicine , genetics , pathology
TheMycobacterium speciesM. tuberculosis, M. avium-intracellulare, M. kansasii, M. marinum, M. scrofulaceum, M. fortuitum, M. terrae , andM. gordonae were analyzed for their susceptibility to rifampin.M. tuberculosis, M. kansasii , andM. marinum were susceptible to the antibiotic, and resistant populations developed as a result of the interplay of mutation and selection. The mutation rates (susceptibility → resistance) were calculated to be 4.9 × 10−10 and 1.7 × 10−9 mutations per bacterium per generation in, respectively,M. kansasii andM. marinum. M. fortuitum was found to be naturally resistant to the antibiotic, whereas the nature of resistance in the other species was unclear and is discussed.