Open AccessEffect of Acyclovir on Latent Herpes Simplex Virus Infections in Trigeminal Ganglia of Mice
Author(s) -
Richard J.T. Klein,
Eugene DeStefano,
Alvin E. FriedmanKien,
Eileen Brady
Publication year - 1981
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.19.5.937
Subject(s) - trigeminal ganglion , herpes simplex virus , latent virus , virology , aciclovir , simplexvirus , virus , herpesviridae , in vitro , medicine , alphaherpesvirinae , pharmacology , biology , viral disease , neuroscience , biochemistry , sensory system
The inhibition by acyclovir of the in vitro reactivation of herpes simplex virus from latently infected ganglion explant cultures is dependent on the continuous presence of this drug. Administration of acyclovir subcutaneously, orally, or by continuous perfusion to mice with established latent infections did not eliminate latent virus from the trigeminal ganglia.