Open AccessAssays of serum aminoglycoside levels by BACTEC 460 in the presence of cefamandole and cefoxitin
Author(s) -
L. E. Phillips,
R. F. Martin,
W. E. Luper,
Thomas E. Rogers
Publication year - 1981
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.19.4.567
Subject(s) - cefamandole , cefoxitin , tobramycin , amikacin , aminoglycoside , cephalosporin , medicine , gentamicin , microbiology and biotechnology , serum concentration , antibiotics , pharmacology , chemistry , biology , bacteria , staphylococcus aureus , genetics
The effects of cefamandole and cefoxitin on the assays of serum containing gentamicin, tobramycin, or amikacin by the BACTEC 460 (Johnston Laboratories, Cockeysville, Md.) were studied. The results were analyzed to determine whether the presence of the test substances, cefamandole or cefoxitin, caused a statistically different mean value of aminoglycoside or increase in variance as compared with serum assayed in their absence. The results were then considered in light of medical significance to see whether the difference observed would have any real effect on patient care. The results of each analyses dictate that serum of patients treated with both amikacin and cefamandole be tested in triplicate.