Biliary concentrations of piperacillin in patients undergoing cholecystectomy | Zendy

J Giron | Zendy; Burt R. Meyers | Zendy; Shalom Z. Hirschman | Zendy

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Biliary concentrations of piperacillin in patients undergoing cholecystectomy

Author(s) -

J Giron,

Burt R. Meyers,

Shalom Z. Hirschman

Publication year - 1981

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.19.2.309

Subject(s) - piperacillin , bilirubin , cholecystectomy , medicine , gastroenterology , common bile duct , antibacterial agent , creatinine , antibiotics , chemistry , pseudomonas aeruginosa , biology , biochemistry , bacteria , genetics

Piperacillin is a new semisynthetic, expanded-spectrum penicillin with marked activity against Pseudomonas aeruginosa. The biliary excretion of piperacillin was studied in patients undergoing cholecystectomy. Concentrations of piperacillin in common duct bile at 35 to 90 min postinfusion of 1-g doses ranged from 31 to 920 micrograms/ml, with a mean (+/- standard deviation) of 467 +/- 363 micrograms/ml. Gallbladder piperacillin levels at 30 to 75 min postinfusion ranged from 2.2 to 80 micrograms/ml, with a mean of 27 +/- 31 micrograms/ml. No correlation occurred with peak serum level of antibiotic, creatinine, bilirubin, or alkaline phosphatase. Significant amounts of piperacillin were excreted via the biliary system.

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