Open AccessN-formimidoyl thienamycin (MK0787): in vitro study
Author(s) -
Smith Shadomy,
Richard May
Publication year - 1981
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.19.1.201
Subject(s) - thienamycin , chemistry , amikacin , cefotaxime , moxalactam , imipenem , minimum inhibitory concentration , microbiology and biotechnology , antibiotics , in vitro , staphylococcus aureus , biochemistry , bacteria , antibiotic resistance , biology , genetics
N-Formimidoyl thienamycin (MK0787) was compared in vitro with three other beta-lactam and two aminoglycoside antibiotics. It was second in activity only to cefotaxime against members of the Enterobacteriaceae and to amikacin against Pseudomonas species. It was the most active antibiotic against Staphylococcus aureus. Resistance (minimal inhibitory concentration, greater than 128 microgram/ml) to N-formimidoyl thienamycin was not observed.