In vitro activity of N-formimidoyl thienamycin (MK0787) | Zendy

Francis P. Tally | Zendy; N V Jacobus | Zendy; S. L. Gorbach | Zendy

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In vitro activity of N-formimidoyl thienamycin (MK0787)

Author(s) -

Francis P. Tally,

N V Jacobus,

S. L. Gorbach

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.18.4.642

Subject(s) - thienamycin , chemistry , penicillin , anaerobic bacteria , bacteria , in vitro , microbiology and biotechnology , imipenem , stereochemistry , biochemistry , antibiotics , biology , antibiotic resistance , genetics

The in vitro activity of N-formimidoyl thienamycin (MK0787), a stable congener of thienamycin, was determined against 200 species of aerobic and 84 species of anaerobic bacteria. The compound was highly active against resistant gram-negative bacilli, penicillin-resistant Staphylococcus aureus, enterococci, and anaerobic bacteria. The new derivative of thienamycin was more active than the parent compound, probably reflecting the stability of the analog.

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