Open AccessComparative nephrotoxicities of high-dose netilmicin and tobramycin in rats
Author(s) -
Richard Parker,
David N. Gilbert,
Donald C. Houghton,
George A. Porter,
William M. Bennett
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.18.2.346
Subject(s) - netilmicin , tobramycin , nephrotoxicity , aminoglycoside , medicine , gentamicin , renal function , pharmacology , anesthesia , antibiotics , kidney , biology , microbiology and biotechnology
The nephrotoxic potentials of netilmicin and tobramycin given in doses of 180 mg/kg per day for up to 14 days were compared in Fischer rats. At this dosage, tobramycin produced mortality and significant changes in renal structure and function; netilmicin evoked minimal nephrotoxicity.