In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans | Zendy

Jørgen Slots | Zendy; R. T. Evans | Zendy; Phyllis M. Lobbins | Zendy; Robert J. Genco | Zendy

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In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans

Author(s) -

Jørgen Slots,

R. T. Evans,

Phyllis M. Lobbins,

Robert J. Genco

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.18.1.9

Subject(s) - carbenicillin , minocycline , actinobacillus , microbiology and biotechnology , tetracycline , antimicrobial , penicillin , ampicillin , agar dilution , chloramphenicol , antibiotics , erythromycin , biology , chemistry , minimum inhibitory concentration , bacteria , genetics

The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less than or equal to 2 micrograms/ml; 89% of the strains were inhibited by 2 micrograms of carbenicillin per ml. The other antimicrobial agents tested were less active. Approximately 10% of the A. actinomycetemcomitans strains were resistant to ampicillin, erythromycin, and penicillin G at concentrations of 32 to 64 micrograms/ml. These data suggest that tetracycline and minocycline may be valuable drugs in the treatment of A. actinomycetemcomitans infections.

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