Open AccessCefoperazone (T-1551), a new semisynthetic cephalosporin: comparison with cephalothin and gentamicin
Author(s) -
Ronald N. Jones,
Peter Fuchs,
Arthur L. Barry,
Thomas L. Gavan,
Herbert M. Sommers,
E. Gerlach
Publication year - 1980
Publication title -
antimicrobial agents and chemotherapy
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 2.07
H-Index - 259
eISSN - 1070-6283
pISSN - 0066-4804
DOI - 10.1128/aac.17.4.743
Subject(s) - cefoperazone , gentamicin , cephalosporin , microbiology and biotechnology , chemistry , biology , antibiotics , antibiotic resistance , imipenem
The in vitro activity of cefoperazone (T-1551) against almost 9,000 recent clinical isolates at six institutions was tested and compared with that of cephalothin and gentamicin. The modal minimum inhibitory concentrations of cefoperazone were 16- and 4-fold less than those of cephalothin and gentamicin, respectively, against 5,503 strains of Enterobacteriaceae. Species normally resistant to cephalothin, such as indole-positive protease and enterobacters, were almost universally susceptible to cefoperazone. Cefoperazone demonstrated activity comparable to gentamicin against Pseudomonas aeruginosa and other pseudomonads.