Structures and antimicrobial activity of peniophorin A and B, two polyacetylenic antibiotics from Peniophora affinis Burt | Zendy

Nancy N. Gerber | Zendy; Stefanie Shaw | Zendy; Hubert A. Lechevalier | Zendy

Open Access

Structures and antimicrobial activity of peniophorin A and B, two polyacetylenic antibiotics from Peniophora affinis Burt

Author(s) -

Nancy N. Gerber,

Stefanie Shaw,

Hubert A. Lechevalier

Publication year - 1980

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.17.4.636

Subject(s) - proteus vulgaris , antibiotics , antimicrobial , strain (injury) , antibacterial activity , stereochemistry , microbiology and biotechnology , chemistry , acetic acid , antifungal , bacteria , biology , biochemistry , genetics , anatomy

Two polyacetylenic antibiotics, peniophorin A and B, have been isolated from a strain of Peniophora affinis. Both have antibacterial and antifungal activity, but B is 3 to 20 times more active than A. Gram-positive cocci and a strain of Proteus vulgaris were especially susceptible to these two antibiotics. Both peniophorins contained an aromatic ring; B was an acid, and A was neutral. Peniophorin B was shown to be 2-(1-oxo-2,4-pentadiynl)phenyl acetic acid. The structure of A was only partially elucidated; it is suspected to be 6-[2-(1-oxo-2,4-pentadiynl)phenyl]5-methoxy-3-oxo-4-hexene-1-ol.

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