Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis | Zendy

Kuni Takayama | Zendy; Emma Lee Armstrong | Zendy; Keith A. Kunugi | Zendy; J O Kilburn | Zendy

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Inhibition by Ethambutol of Mycolic Acid Transfer into the Cell Wall of Mycobacterium smegmatis

Author(s) -

Kuni Takayama,

Emma Lee Armstrong,

Keith A. Kunugi,

J O Kilburn

Publication year - 1979

Publication title -

antimicrobial agents and chemotherapy

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 2.07

H-Index - 259

eISSN - 1070-6283

pISSN - 0066-4804

DOI - 10.1128/aac.16.2.240

Subject(s) - mycobacterium smegmatis , ethambutol , trehalose , mycolic acid , cell wall , mycobacterium , antimycobacterial , microbiology and biotechnology , biochemistry , chemistry , mycobacterium tuberculosis , bacteria , biology , antibiotics , rifampicin , tuberculosis , medicine , pathology , genetics

Ethambutol simultaneously inhibited the transfer (presumably via mycolyl acetyl trehalose) of mycolic acids into the cell wall and stimulated the synthesis of trehalose dimycolates ofMycobacterium smegmatis . Structural similarities of the drug and mycolyl acetyl trehalose suggested that competitive inhibition was involved.

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